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Endothelial protein C receptor
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Endothelial protein C receptor : ウィキペディア英語版
Endothelial protein C receptor

Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is a protein that in humans is encoded by the ''PROCR'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10544 )〕 PROCR has also recently been designated CD201 (cluster of differentiation 201).
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C.〔
== Clinical significance ==

Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10544 )
The protein is also involved in ''Plasmodium falciparum'' malaria as subtypes of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family use EPCR of the host as a receptor.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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